This article provides information on the best dietary supplements for depression. The supplements were chosen based on specific criteria, including evidence-based research, third-party testing, high-quality ingredients, and affordability. The article includes subsections for each of the best supplements, including Pure Encapsulations Rhodiola Rosea, NOW Saffron 50 mg, Nordic Naturals EPA Xtra, Pure Encapsulations NAC (N-acetyl-L-cysteine) 900 mg, Thorne Vitamin D/K2 Liquid, Klaire Labs B-Complex Plus, Pure Encapsulations Zinc 15 mg, Jarrow Formulas SAMe 400 mg, Bluebonnet Magnesium Glycinate, and Thorne Creatine.
Best with Rhodiola
Rhodiola is an herb that has been linked to reduced depressive symptoms and improved stress response. Pure Encapsulations Rhodiola Rosea is a great option for those interested in taking a rhodiola supplement. The supplement contains 100 mg of rhodiola rosea, standardized to contain 3% rosavins and 1% salidrosides, which are bioactive components thought to be responsible for rhodiola’s therapeutic effects. Additionally, Pure Encapsulations is a company that takes product quality seriously and exceeds standards set by United States Pharmacopeia (USP).
Best with Saffron
Saffron has shown promise as a natural remedy for depression and has been observed to increase levels of the mood-boosting neurotransmitter serotonin in the brain. NOW Saffron 50 mg provides a dose that has been shown to be effective for reducing symptoms of depression and is affordable and easy to find at most nationwide pharmacies. NOW supplements are made in a facility that’s certified by Underwriters Laboratory and exceeds the current good manufacturing practices (CGMPs).
Best with Omega-3s
Omega-3 fats are essential fats that some studies show may help reduce depressive symptoms in some people. Nordic Naturals EPA Xtra provides 1,060 mg of EPA and 260 mg of DHA per 2-softgel serving, making it a great option for those looking to add omega-3s to their diet. Nordic Naturals fish oil products are third-party tested to ensure the product meets strict standards for purity, potency, and freshness.
Best with N-acetyl-L-cysteine
NAC is a precursor to the amino acids L-cysteine and glutathione and has been shown to offer several health benefits, including boosting your body’s glutathione levels. Pure Encapsulations NAC (N-acetyl-L-cysteine) 900 mg is a great NAC supplement because it contains just one active ingredient and is tested multiple times throughout manufacturing.
Best with Vitamin D
Vitamin D is a critical nutrient that plays numerous essential roles in your body. Thorne Vitamin D/K2 Liquid provides both vitamin D3 and vitamin K2, making it a great option for those looking to supplement their vitamin D intake. The supplement is affordable and easy to take, with a dosage of 2 drops 1–3 times per day.
Best with B Vitamins
B vitamins are essential for a healthy nervous system and may help alleviate symptoms of depression. Klaire Labs B-Complex Plus is a great option for those looking to supplement their B vitamin intake. The supplement contains all eight B vitamins in their active forms, making them easily absorbed by the body.
Best with Zinc
Zinc is an essential mineral that may help reduce symptoms of depression. Pure Encapsulations Zinc 15 mg is a great option for those looking to supplement their zinc intake. The supplement contains 15 mg of zinc in the form of zinc picolinate, which is easily absorbed by the body.
Best with SAMe
SAMe is a molecule that plays a role in numerous biological processes and has been shown to alleviate symptoms of depression. Jarrow Formulas SAMe 400 mg is a great option for those looking to supplement their SAMe intake. The supplement is affordable and easy to take, with a dosage of 1 tablet 1–2 times per day.
Best with Magnesium
Magnesium is an essential mineral that plays a role in numerous biological processes and may help alleviate symptoms of depression. Bluebonnet Magnesium Glycinate is a great option for those looking to supplement their magnesium intake. The supplement contains 200 mg of magnesium in the form of magnesium glycinate, which is easily absorbed by the body.
Best with Creatine
Creatine is a molecule that plays a role in energy production and has been shown to alleviate symptoms of depression. Thorne Creatine is a great option for those looking to supplement their creatine intake. The supplement is affordable and easy to take, with a dosage of 1 scoop per day.